Division of Maternal-Fetal Medicine, Department of Obstetrics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
J Womens Health (Larchmt). 2010 May;19(5):941-50. doi: 10.1089/jwh.2009.1660.
Lactation has been associated with reduced risk of type 2 diabetes and the metabolic syndrome in mothers. We examined the relation between breastfeeding duration and metabolic markers at 3 years postpartum.
We used linear regression to relate duration of lactation to maternal glucose and lipid metabolism, inflammatory markers, and anthropometry at 3 years postpartum among 570 participants with 3-year blood samples (175 fasting) in Project Viva, a cohort study of mothers and children.
Among the participants, 88% had initiated breastfeeding, and 26% had breastfed >or=12 months. In multivariate analyses, we observed no consistent trends relating duration of lactation to maternal metabolism at 3 years postpartum. Women who exclusively breastfed for >6 months had lower postpartum weight retention at 3 years than women with shorter durations of exclusive breastfeeding (multivariate adjusted predicted mean -0.5, -3.6-2.6 kg vs. 4.8, 2.0-7.6 kg for those who never exclusively breastfed, partial F p = 0.03).
In this prospective cohort study, we did not observe a dose-response relationship between duration of lactation and metabolic risk at 3 years postpartum.
哺乳与母亲患 2 型糖尿病和代谢综合征的风险降低有关。我们研究了产后 3 年母乳喂养持续时间与代谢标志物之间的关系。
在 Viva 项目中，我们使用线性回归分析了 570 名有 3 年血样（175 名空腹）的参与者，将母乳喂养持续时间与产后 3 年的母亲血糖和脂质代谢、炎症标志物以及人体测量学指标相关联。该项目是一项对母亲和儿童进行的队列研究。
在参与者中，88%的人开始母乳喂养，26%的人母乳喂养>或=12 个月。在多变量分析中，我们没有观察到母乳喂养持续时间与产后 3 年母亲代谢之间存在一致的趋势。与母乳喂养持续时间较短的女性相比，持续母乳喂养>6 个月的女性在产后 3 年时体重保持率较低（多变量校正后的预测平均值为-0.5，-3.6-2.6kg 与从未进行过纯母乳喂养的女性相比，4.8，2.0-7.6kg，部分 F p = 0.03）。
在这项前瞻性队列研究中，我们没有观察到母乳喂养持续时间与产后 3 年代谢风险之间存在剂量反应关系。
