Department of Medical Microbiology, University Medical Centre Utrecht, The Netherlands.
Clin Microbiol Infect. 2011 Feb;17(2):316-9. doi: 10.1111/j.1469-0691.2010.03260.x.
We quantified nosocomial transmission rates of sequence type (ST) 398 methicillin-resistant Staphylococcus aureus (MRSA) (an emerging livestock-associated MRSA clone) and non-ST398 MRSA isolates in patients hospitalized without infection control measures in 51 Dutch hospitals. Identification of 174 index patients initiated 139 post-exposure screenings of 9925 persons. There were 65 genotype-confirmed secondary cases (three and 62 for ST398 and non-ST398 MRSA, respectively), yielding a relative transmission risk for ST398 MRSA of 0.28 (95% CI 0.09-0.90), which was not sensitive to adjustment for duration of hospitalization at time of detection. Nosocomial transmission of ST398 MRSA is 72% less likely than that of non-ST398 MRSA strains.
我们在 51 家荷兰医院中定量研究了无感染控制措施的住院患者中流行株 398 型（一种新兴的与牲畜相关的耐甲氧西林金黄色葡萄球菌（MRSA）克隆）和非 398 型 MRSA 分离株的医院内传播率。174 名索引患者的鉴定启动了对 9925 人的 139 次接触后筛查。有 65 例基因型确认的继发性病例（分别为 3 例和 62 例流行株 398 型和非 398 型 MRSA），流行株 398 型 MRSA 的相对传播风险为 0.28（95%CI0.09-0.90），而在检测时的住院时间调整后并不敏感。与非 398 型 MRSA 株相比，ST398 MRSA 的医院内传播可能性低 72%。
