Cardiovascular Center and Health Management Center, National Taiwan University Hospital Yun-Lin Branch, Dou-Liou City, Taiwan.
Respir Res. 2010 May 9;11(1):53. doi: 10.1186/1465-9921-11-53.
This study examined whether zinc intake was associated with lower risk of smoking-induced obstructive lung disorder through interplay with cadmium, one of major toxicants in cigarette smoke.
Data were obtained from a sample of 6,726 subjects aged 40+ from the Third National Health and Nutrition Examination Survey. The forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were measured using spirometry. Gender-, ethnicity-, and age-specific equations were used to calculate the lower limit of normal (LLN) to define obstructive lung disorder as: observed FEV1/FVC ratio and FEV1 below respective LLN. Zinc intake was assessed by questionnaire. Logistic regression analysis was applied to investigate the associations of interest.
The analyses showed that an increased prevalence of obstructive lung disorder was observed among individuals with low zinc intake regardless of smoking status. The adjusted odds of lung disorder are approximately 1.9 times greater for subjects in the lowest zinc-intake tertile than those in the highest tertile (odds ratio = 1.89, 95% confidence interval = 1.22-2.93). The effect of smoking on lung function decreased considerably after adjusting for urinary cadmium. Protective association between the zinc-to-cadmium ratio (log-transformed) and respiratory risk suggests that zinc may play a role in smoking-associated lung disorder by modifying the influence of cadmium.
While zinc intake is associated with lower risk of obstructive lung disorder, the role of smoking cession and/or prevention are likely to be more important given their far greater effect on respiratory risk. Future research is warranted to explore the mechanisms by which zinc could modify smoking-associated lung disease.
本研究旨在探讨锌的摄入量是否通过与镉相互作用（镉是香烟烟雾中的主要有毒物质之一）与吸烟引起的阻塞性肺疾病的风险降低有关。
数据来自第三次全国健康和营养调查的 6726 名 40 岁以上的受试者。使用肺活量计测量第一秒用力呼气量（FEV1）和用力肺活量（FVC）。使用性别、种族和年龄特异性方程计算正常下限（LLN），以定义阻塞性肺疾病为：观察到的 FEV1/FVC 比值和 FEV1 均低于相应的 LLN。锌摄入量通过问卷进行评估。应用逻辑回归分析研究相关关联。
分析表明，无论吸烟状况如何，低锌摄入的个体中观察到阻塞性肺疾病的患病率增加。最低锌摄入量 tertile 的受试者发生肺疾病的调整比值比（OR）约为最高 tertile 的 1.9 倍（OR=1.89，95%置信区间为 1.22-2.93）。调整尿镉后，吸烟对肺功能的影响大大降低。锌与镉比值（对数转换）与呼吸风险之间的保护关联表明，锌可能通过改变镉的影响在吸烟相关的肺疾病中发挥作用。
虽然锌的摄入量与阻塞性肺疾病的风险降低有关，但鉴于吸烟戒断和/或预防对呼吸风险的影响要大得多，它们可能更重要。需要进一步研究探索锌如何通过改变与吸烟相关的肺部疾病的机制。
