Ogura H, Harms E, Rohrschneider J M, Bauer H
Intervirology. 1978;10(1):1-10. doi: 10.1159/000148962.
Japanese quail cells transformed by the replication-defective, Bryan high-titer strain of Rous sarcoma virus, BH RSV(-)Q, clone 3, revealed intracytoplasmic A-type particles after dexamethasone treatment. In the absence of dexamethasone, or when superinfected with a helper virus in the presence or absence of dexamethasone, no such particles were observed. Chick embryo cells (CEC) infected with a temperature-sensitive sarcoma virus mutant, LA 334, coordinately defective for transformation and viral replication, showed abnormal accumulation of viral core substances and aberrant budding at the non-permissive temperature (41 degrees). CEC infected with LA 334 and treated with dexamethasone at 41 degrees resulted in more extensive accumulation of abnormal budding without increased release of viral particles. Dexamethasone, however, did not lead to abnormal morphogenesis of virus under permissive conditions. The selective effects of dexamethasone on the morphogenesis of these two mutants of avian sarcoma virus are discussed.
经复制缺陷型的 Bryan 高滴度劳斯肉瘤病毒（BH RSV(-)Q）克隆 3 转化的日本鹌鹑细胞，在用地塞米松处理后，显示出胞质内 A 型颗粒。在没有地塞米松的情况下，或者在有或没有地塞米松时用辅助病毒超感染时，未观察到此类颗粒。用对转化和病毒复制均有缺陷的温度敏感型肉瘤病毒突变体 LA 334 感染的鸡胚细胞（CEC），在非允许温度（41 摄氏度）下显示出病毒核心物质的异常积累和异常出芽。在 41 摄氏度下用 LA 334 感染并用 地塞米松处理的 CEC 导致异常出芽的积累更广泛，但病毒颗粒释放未增加。然而，在地塞米松的允许条件下，其不会导致病毒的异常形态发生。本文讨论了地塞米松对这两种禽肉瘤病毒突变体形态发生的选择性作用。
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