Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 201203, China.
Mol Genet Genomics. 2021 Sep;296(5):1027-1040. doi: 10.1007/s00438-021-01804-y. Epub 2021 Jun 17.
Psoriasis is a chronic inflammatory skin disease characterized by excessive proliferation of keratinocytes (KCs). Onset of psoriasis is related to genetic, immune and environmental factors. The environment can interact with the genome through epigenetic modifications, including DNA methylation, and this modification is involved in the pathogenesis of psoriasis. In addition to a skin disease, psoriasis is also considered a systemic disease. We reviewed the current literature of psoriatic DNA methylation for studies from several aspects on the DNA methylation distribution patterns in different tissues/cells, single-nucleotide polymorphisms, and candidate disease genes and identified target genes regulated by DNA methylation that have been directly/indirectly validated. This review contributes to a comprehensive understanding of the important a role that DNA methylation plays in psoriasis from a holistic perspective and will promote the implementation of DNA methylation in diagnostic and therapeutic strategies for psoriatic patients.
银屑病是一种慢性炎症性皮肤病，其特征是角质形成细胞（KCs）过度增殖。银屑病的发病与遗传、免疫和环境因素有关。环境可以通过表观遗传修饰（包括 DNA 甲基化）与基因组相互作用，这种修饰参与了银屑病的发病机制。银屑病不仅是一种皮肤病，还被认为是一种全身性疾病。我们综述了银屑病 DNA 甲基化的最新文献，从多个方面研究了不同组织/细胞中 DNA 甲基化的分布模式、单核苷酸多态性和候选疾病基因，并确定了受 DNA 甲基化调控的靶基因，这些靶基因已被直接/间接验证。这篇综述有助于从整体角度全面了解 DNA 甲基化在银屑病中的重要作用，并将促进 DNA 甲基化在银屑病患者诊断和治疗策略中的应用。
