Department of Infection and Tropical Medicine, Royal Hallamshire Hospital, Sheffield S10 2JF, UK.
J Antimicrob Chemother. 2010 Jul;65(7):1510-3. doi: 10.1093/jac/dkq152. Epub 2010 May 11.
Infections with extended-spectrum-beta-lactamase-producing organisms are an increasing public health concern. We reviewed the use of an outpatient parenteral antibiotic therapy (OPAT) programme to facilitate the early discharge from hospital of patients with ESBL-associated urinary tract infections.
A retrospective review of patients treated for urinary tract infections caused by ESBL-producing organisms through the OPAT programme at the Royal Hallamshire Hospital, Sheffield, UK over a 4 year period to January 2010 was conducted. Data on patient demographics, clinical presentation and laboratory results were collected.
Twenty-four OPAT episodes involving 11 patients were identified. Six patients (54.5%) had an underlying urological abnormality on presentation to OPAT. All patients were treated with parenteral ertapenem. Two patients had multiple infections treated by OPAT. The mean duration of the OPAT episodes was 9.9 days (range 3-42). A total of 238 inpatient bed days were avoided, with resultant cost savings.
Ertapenem administration through OPAT may help to decrease the costs associated with ESBL infections by reducing the number of inpatient bed days required for their successful treatment.
产超广谱β-内酰胺酶（ESBL）的生物体感染是一个日益严重的公共卫生问题。我们回顾了使用门诊静脉注射抗生素治疗（OPAT）方案来促进患有 ESBL 相关性尿路感染的患者早日出院。
对英国谢菲尔德皇家哈利姆沙尔医院在 2010 年 1 月前的 4 年时间内通过 OPAT 方案治疗的由产 ESBL 生物体引起的尿路感染患者进行回顾性分析。收集患者的人口统计学、临床表现和实验室结果数据。
共确定了 24 例涉及 11 名患者的 OPAT 治疗方案。6 名患者（54.5%）在开始 OPAT 时就存在泌尿系统异常。所有患者均接受了注射用厄他培南治疗。有 2 名患者有多重感染接受了 OPAT 治疗。OPAT 治疗方案的平均持续时间为 9.9 天（范围 3-42 天）。共避免了 238 个住院日，节省了成本。
通过 OPAT 给予厄他培南治疗可能有助于通过减少成功治疗所需的住院天数来降低与 ESBL 感染相关的成本。
