《百万妇女研究》中吸烟与听神经瘤和垂体瘤风险的关系。
Cigarette smoking and risk of acoustic neuromas and pituitary tumours in the Million Women Study.
机构信息
Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, UK.
出版信息
Br J Cancer. 2010 May 25;102(11):1654-6. doi: 10.1038/sj.bjc.6605695. Epub 2010 May 11.
BACKGROUND
The relationship between cigarette smoking and incidence of acoustic neuromas and pituitary tumours is uncertain.
METHODS
We examined the relation between smoking and risk of acoustic neuromas and pituitary tumours in a prospective study of 1.2 million middle-aged women in the United Kingdom.
RESULTS
Over 10.2 million person years of follow-up, 177 women were diagnosed with acoustic neuromas and 174 with pituitary tumours. Current smokers at recruitment were at significantly reduced risk of incident acoustic neuroma compared with never smokers (adjusted relative risk (RR)=0.41, 95% confidence interval (CI)=0.24-0.70, P=0.001). Past smokers did not have significantly different risk of acoustic neuroma than never smokers (RR=0.87, 95% CI=0.62-1.22, P=0.4). Smoking was not associated with incidence of pituitary tumours (RR in current vs never smokers=0.91, 95% CI=0.60-1.40, P=0.7).
CONCLUSION
Women who smoke are at a significantly reduced risk of acoustic neuromas, but not of pituitary tumours, compared with never smokers. Acoustic neuromas are much rarer than the cancers that are increased among smokers.
背景
吸烟与听神经瘤和垂体瘤发病率之间的关系尚不确定。
方法
我们在英国一项针对 120 万名中年女性的前瞻性研究中，研究了吸烟与听神经瘤和垂体瘤风险之间的关系。
结果
在超过 1020 万人年的随访中，有 177 名女性被诊断为听神经瘤，174 名女性被诊断为垂体瘤。与从不吸烟者相比，招募时的现吸烟者发生听神经瘤的风险显著降低（调整后的相对风险（RR）=0.41，95%置信区间（CI）=0.24-0.70，P=0.001）。过去吸烟者与从不吸烟者相比，发生听神经瘤的风险无显著差异（RR=0.87，95% CI=0.62-1.22，P=0.4）。吸烟与垂体瘤的发病率无关（当前吸烟者与从不吸烟者的 RR=0.91，95% CI=0.60-1.40，P=0.7）。
结论
与从不吸烟者相比，吸烟的女性发生听神经瘤的风险显著降低，但发生垂体瘤的风险没有差异。听神经瘤比吸烟者中增加的癌症罕见得多。
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