Asa Sylvia L, Ezzat Shereen
Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network and Ontario Cancer Institute, Toronto, Ontario, Canada.
Annu Rev Pathol. 2009;4:97-126. doi: 10.1146/annurev.pathol.4.110807.092259.
Recently there has been significant progress in our understanding of pituitary development, physiology, and pathology. New information has helped to clarify the classification of pituitary tumors. Epidemiologic analyses have identified a much higher incidence of pituitary tumors than previously thought. We review the pathogenetic factors that have been implicated in pituitary tumorigenesis and the application of novel targeted therapies that underscore the increasingly important role of the pathologist in determining accurate diagnoses and facilitating appropriate treatment of patients with these disorders.
最近，我们对垂体发育、生理学和病理学的理解取得了重大进展。新信息有助于明确垂体肿瘤的分类。流行病学分析发现垂体肿瘤的发病率比之前认为的要高得多。我们回顾了与垂体肿瘤发生相关的致病因素，以及新型靶向治疗的应用，这些都凸显了病理学家在准确诊断和促进这些疾病患者的适当治疗方面日益重要的作用。
