Division of Epidemiology, College of Public Health, Ohio State University, Columbus, USA.
Am J Epidemiol. 2012 Jun 15;175(12):1243-51. doi: 10.1093/aje/kwr465. Epub 2012 Apr 19.
Two previous studies suggest that cigarette smoking reduces acoustic neuroma risk; however, an association between use of snuff tobacco and acoustic neuroma has not been investigated previously. The authors conducted a case-control study in Sweden from 2002 to 2007, in which 451 cases and 710 population-based controls completed questionnaires. Cases and controls were matched on gender, region, and age within 5 years. The authors estimated odds ratios using conditional logistic regression analyses, adjusted for education and tobacco use (snuff use in the smoking analysis and smoking in the snuff analysis). The risk of acoustic neuroma was greatly reduced in male current smokers (odds ratio (OR) = 0.41, 95% confidence interval (CI): 0.23, 0.74) and moderately reduced in female current smokers (OR = 0.70, 95% CI: 0.40, 1.23). In contrast, current snuff use among males was not associated with risk of acoustic neuroma (OR = 0.94, 95% CI: 0.57, 1.55). The authors' findings are consistent with previous reports of lower acoustic neuroma risk among current cigarette smokers than among never smokers. The absence of an association between snuff use and acoustic neuroma suggests that some constituent of tobacco smoke other than nicotine may confer protection against acoustic neuroma.
先前有两项研究表明，吸烟会降低听神经瘤的风险；然而，鼻烟的使用与听神经瘤之间的关联尚未被研究过。作者在 2002 年至 2007 年间在瑞典进行了一项病例对照研究，其中 451 例病例和 710 例基于人群的对照完成了问卷调查。病例和对照在性别、地区和 5 年内的年龄方面进行了匹配。作者使用条件逻辑回归分析估计了比值比，调整了教育程度和烟草使用（吸烟分析中的鼻烟使用和鼻烟分析中的吸烟）。男性当前吸烟者的听神经瘤风险大大降低（比值比（OR）=0.41，95%置信区间（CI）：0.23，0.74），女性当前吸烟者的风险适度降低（OR=0.70，95%CI：0.40，1.23）。相比之下，男性当前使用鼻烟与听神经瘤风险无关（OR=0.94，95%CI：0.57，1.55）。作者的发现与先前关于当前吸烟者比从不吸烟者听神经瘤风险较低的报告一致。鼻烟使用与听神经瘤之间没有关联表明，烟草烟雾中的某些成分除了尼古丁之外，可能对听神经瘤具有保护作用。
