乙型肝炎与肾脏疾病
Hepatitis B and Renal Disease.
作者信息
Chan Tak Mao
机构信息
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.
出版信息
Curr Hepat Rep. 2010 May;9(2):99-105. doi: 10.1007/s11901-010-0042-6. Epub 2010 Apr 14.
Abstract
Glomerulonephritis is an important extrahepatic manifestation of chronic hepatitis B virus (HBV) infection. The uncommon occurrence, variability in renal histopathology, and heterogeneity in clinical course present challenges in clinical studies and have resulted in a relative paucity of data and uncertainty with regard to the optimal management of HBV-related glomerular diseases. The advent of nucleos(t)ide analogue medications that effectively suppress HBV replication has markedly altered the clinical outcomes of kidney transplant recipients with HBV infection, but the emergence of drug resistance is an escalating problem. This article reviews the recent knowledge of the pathogenesis and treatment of HBV-related membranous nephropathy, and discusses the management of hepatitis B in kidney transplant recipients, which is continuously evolving.
摘要
肾小球肾炎是慢性乙型肝炎病毒（HBV）感染的一种重要肝外表现。其发生率低、肾脏组织病理学表现多样以及临床病程异质性给临床研究带来了挑战，导致有关HBV相关肾小球疾病的最佳管理的数据相对较少且存在不确定性。有效抑制HBV复制的核苷（酸）类似物药物的出现显著改变了HBV感染肾移植受者的临床结局，但耐药性的出现是一个日益严重的问题。本文综述了HBV相关膜性肾病发病机制和治疗的最新知识，并讨论了肾移植受者中乙型肝炎的管理，这一领域仍在不断发展。
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