乙型肝炎病毒感染作为慢性肾脏病的危险因素：系统评价和荟萃分析。
Hepatitis B virus infection as a risk factor for chronic kidney disease: a systematic review and meta-analysis.
机构信息
Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, 350122, People's Republic of China.
Department of Epidemiology and Health Statistics, Key Laboratory of Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Ministry of Education, Fujian Medical University, Xuefu North Road 1st, Shangjie Town, Minhou Country, Fuzhou, Fujian, 350108, China.
出版信息
BMC Infect Dis. 2024 Jun 22;24(1):620. doi: 10.1186/s12879-024-09546-z.
BACKGROUND
Currently, several studies have observed that chronic hepatitis B virus infection is associated with the pathogenesis of kidney disease. However, the extent of the correlation between hepatitis B virus infection and the chronic kidney disease risk remains controversial.
METHODS
In the present study, we searched all eligible literature in seven databases in English and Chinese. The random effects model was used to conduct a meta-analysis. Quality of included studies was assessed using the Newcastle-Ottawa Quality Scale.
RESULTS
In this analysis, a total of 31 studies reporting the association between hepatitis B virus infection and chronic kidney disease risk were included. The results showed a significant positive association between hepatitis B virus infection and the risk of chronic kidney disease (pooled OR, 1.20; 95% CI, 1.12-1.29), which means that hepatitis B virus increases the risk of developing chronic kidney disease.
CONCLUSION
This study found that hepatitis B virus infection was associated with a significantly increased risk of chronic kidney disease. However, the current study still cannot directly determine this causal relationship. Thus, more comprehensive prospective longitudinal studies are needed in the future to provide further exploration and explanation of the association between hepatitis B virus and the risk of developing chronic kidney disease.
背景
目前，已有多项研究观察到慢性乙型肝炎病毒感染与肾脏病发病机制有关。然而，乙型肝炎病毒感染与慢性肾脏病风险之间的相关性程度仍存在争议。
方法
本研究在英文和中文七个数据库中检索了所有合格的文献。采用随机效应模型进行荟萃分析。使用纽卡斯尔-渥太华质量量表评估纳入研究的质量。
结果
本分析共纳入了 31 项报告乙型肝炎病毒感染与慢性肾脏病风险之间关联的研究。结果表明，乙型肝炎病毒感染与慢性肾脏病风险之间存在显著正相关（合并 OR，1.20；95%CI，1.12-1.29），这意味着乙型肝炎病毒增加了发生慢性肾脏病的风险。
结论
本研究发现乙型肝炎病毒感染与慢性肾脏病风险显著增加相关。然而，目前的研究仍不能直接确定这种因果关系。因此，未来需要更全面的前瞻性纵向研究，以进一步探索和解释乙型肝炎病毒与慢性肾脏病风险之间的关联。
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