Takeishi Y, Tono-Oka I, Meguro M, Chiba J, Abe S, Tsuiki K, Komatani A, Kera M, Takanashi I, Takahashi K
First Department of Internal Medicine, Department of Radiology, Yamagata University Hospital, Yamagata University School of Medicine.
Kaku Igaku. 1991 Mar;28(3):297-300.
The aim of this study was to assess whether or not myocardial uptake of Technetium-99m methoxy isobutyl isonitrile (Tc-MIBI) indicated myocardial viability. We performed simultaneous Tc-MIBI angiography and myocardial SPECT at rest on 12 patients with suspected coronary artery disease. Left ventricle was divided into 3 segments, and regional wall motion was graded as normal, hypokinesis and akinesis/dyskinesis. Myocardial uptake of Tc-MIBI was assessed as normal, reduced and absent in each segment. In segments with normal and reduced Tc-MIBI uptake, 7% (2 of 28) and 33% (2 of 6) showed wall motion abnormalities of akinesis/dyskinesis, respectively. However, all segments with absent Tc-MIBI uptake had asynergy of akinesis/dyskinesis (2 of 2, 100%). Myocardial Tc-MIBI uptake at rest indicated wall motion abnormalities and was considered to be useful for the evaluation of myocardial viability. First-pass radionuclide angiography followed by myocardial SPECT with Tc-MIBI demonstrated to be useful for the simultaneous assessment of the left ventricular wall motion and myocardial perfusion.
本研究的目的是评估锝-99m甲氧基异丁基异腈（Tc-MIBI）的心肌摄取是否表明心肌存活。我们对12例疑似冠心病患者在静息状态下同时进行了Tc-MIBI血管造影和心肌单光子发射计算机断层扫描（SPECT）。左心室分为3个节段，局部室壁运动分为正常、运动减弱和运动消失/运动障碍。评估每个节段Tc-MIBI的心肌摄取为正常、降低和缺失。在Tc-MIBI摄取正常和降低的节段中，分别有7%（28个节段中的2个）和33%（6个节段中的2个）表现为运动消失/运动障碍的室壁运动异常。然而，所有Tc-MIBI摄取缺失的节段均有运动消失/运动障碍的运动不协调（2个节段中的2个，100%）。静息状态下心肌Tc-MIBI摄取表明室壁运动异常，被认为对评估心肌存活有用。首次通过放射性核素血管造影随后进行Tc-MIBI心肌SPECT被证明对同时评估左心室壁运动和心肌灌注有用。
