Morita T
Department of Urology, Akita University School of Medicine.
Nihon Hinyokika Gakkai Zasshi. 1991 Jan;82(1):61-6. doi: 10.5980/jpnjurol1989.82.61.
I investigated the biochemical (Bmax, KD) and functional (contractile force) characteristics of autonomic receptors in the 1-day-old rabbit urinary tract smooth muscle, and compared the data obtained to those already reported in adult rabbits. The rank order of the receptor densities in neonatal rabbits are dome greater than base greater than urethra greater than ureter for alpha 1 (3H-PZ), ureter greater than urethra greater than base greater than dome for alpha 2 (3H-YOH), dome greater than base greater than urethra greater than ureter for beta (3H-DHA) and dome greater than base greater than urethra greater than ureter for muscarinic (3H-QNB). Unlike the findings in the adult rabbit, there is a much larger number of functional muscarinic receptors in the bladder dome and a much smaller number of functional alpha 1-receptors in the urethra of neonatal rabbits. The differences observed in the pattern of distribution of these receptors between neonatal and adult urinary tracts may play a determinant role in the physiological development of the urinary system.
我研究了1日龄兔泌尿道平滑肌中自主神经受体的生化特性（最大结合容量、解离常数）和功能特性（收缩力），并将所得数据与成年兔中已报道的数据进行比较。新生兔中α1（3H-PZ）受体密度的顺序为圆顶大于底部大于尿道大于输尿管，α2（3H-YOH）受体密度顺序为输尿管大于尿道大于底部大于圆顶，β（3H-DHA）受体密度顺序为圆顶大于底部大于尿道大于输尿管，毒蕈碱（3H-QNB）受体密度顺序为圆顶大于底部大于尿道大于输尿管。与成年兔的研究结果不同，新生兔膀胱圆顶中功能性毒蕈碱受体的数量多得多，而尿道中功能性α1受体的数量少得多。在新生和成年泌尿道之间观察到的这些受体分布模式的差异可能在泌尿系统的生理发育中起决定性作用。
