Immunosenescence Unit, Department of Pathobiology and Biomedical Methodologies, University of Palermo, Palermo, Italy.
Rejuvenation Res. 2010 Apr-Jun;13(2-3):301-13. doi: 10.1089/rej.2009.0993.
Alzheimer disease (AD) is a heterogeneous and progressive neurodegenerative disease, which in Western society mainly accounts for senile dementia. Today many countries have rising aging populations and are facing an increased prevalence of age-related diseases, such as AD, with increasing health-care costs. Understanding the pathophysiology process of AD plays a prominent role in new strategies for extending the health of the elderly population. Considering the future epidemic of AD, prevention and treatment are important goals of ongoing research. However, a better understanding of AD pathophysiology must be accomplished to make this objective feasible. In this paper, we review some hot topics concerning AD pathophysiology that have an important impact on therapeutic perspectives. Hence, we have focused our attention on inflammation, cytokines, immune response, apolipoprotein E (APOE), cholesterol, oxidative stress, as well as exploring the related therapeutic possibilities, i.e., nonsteroidal antiinflammatory drugs, cytokine blocking antibodies, immunotherapy, diet, and curcumin.
阿尔茨海默病（AD）是一种异质性和进行性神经退行性疾病，在西方社会主要导致老年性痴呆。如今，许多国家的人口老龄化程度不断上升，面临着与年龄相关的疾病（如 AD）的发病率上升，导致医疗保健成本增加。了解 AD 的病理生理学过程对于制定延长老年人口健康的新策略具有突出作用。考虑到 AD 的未来流行趋势，预防和治疗是正在进行的研究的重要目标。然而，要使这一目标成为可能，就必须更好地了解 AD 的病理生理学。在本文中，我们回顾了一些对治疗前景有重要影响的 AD 病理生理学热点话题。因此，我们将注意力集中在炎症、细胞因子、免疫反应、载脂蛋白 E（APOE）、胆固醇、氧化应激上，并探讨了相关的治疗可能性，如非甾体抗炎药、细胞因子阻断抗体、免疫疗法、饮食和姜黄素。
