Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9589, USA.
Drug Alcohol Depend. 2010 Sep 1;111(1-2):4-12. doi: 10.1016/j.drugalcdep.2010.03.011. Epub 2010 May 11.
Drug addiction research requires but lacks a valid and reliable way to measure both the risk (propensity) to develop addiction and the severity of manifest addiction. This paper argues for a new measurement approach and instrument to quantify propensity to and severity of addiction, based on the testable assumption that these constructs can be mapped onto the same dimension of liability to addiction. The case for this new direction becomes clear from a critical review of empirical data and the current instrumentation. The many assessment instruments in use today have proven utility, reliability, and validity, but they are of limited use for evaluating individual differences in propensity and severity. The conceptual and methodological shortcomings of instruments currently used in research and clinical practice can be overcome through the use of new technologies to develop a reliable, valid, and standardized assessment instrument(s) to measure and distinguish individual variations in expression of the underlying latent trait(s) that comprises propensity to and severity of drug addiction. Such instrumentation would enhance our capacity for drug addiction research on linkages and interactions among familial, genetic, psychosocial, and neurobiological factors associated with variations in propensity and severity. It would lead to new opportunities in substance abuse prevention, treatment, and services research, as well as in interventions and implementation science for drug addiction.
药物成瘾研究需要但缺乏一种有效和可靠的方法来衡量成瘾的风险(倾向)和明显成瘾的严重程度。本文基于这样一个可检验的假设,即这些结构可以映射到成瘾倾向的同一维度,提出了一种新的测量方法和工具来量化成瘾的倾向和严重程度。从对经验数据和当前仪器设备的批判性回顾中可以清楚地看到这一新方向的合理性。目前使用的许多评估工具具有实用价值、可靠性和有效性,但对于评估个体在倾向和严重程度上的差异,它们的用途有限。通过使用新技术来开发可靠、有效和标准化的评估工具,可以克服当前用于研究和临床实践中的工具的概念和方法上的缺陷,从而测量和区分构成药物成瘾倾向和严重程度的潜在潜在特征的个体差异。这种仪器设备将增强我们对与倾向和严重程度变化相关的家族、遗传、心理社会和神经生物学因素之间的联系和相互作用进行药物成瘾研究的能力。它将为物质滥用预防、治疗和服务研究以及药物成瘾的干预和实施科学带来新的机会。