Massachusetts General Hospital, Boston, 02114, USA.
Blood. 2010 Sep 2;116(9):1397-404. doi: 10.1182/blood-2010-03-258608. Epub 2010 May 12.
Plasma cell dyscrasias are frequently encountered malignancies often associated with kidney disease through the production of monoclonal immunoglobulin (Ig). Paraproteins can cause a remarkably diverse set of pathologic patterns in the kidney and recent progress has been made in explaining the molecular mechanisms of paraprotein-mediated kidney injury. Other recent advances in the field include the introduction of an assay for free light chains and the use of novel antiplasma cell agents that can reverse renal failure in some cases. The role of stem cell transplantation, plasma exchange, and kidney transplantation in the management of patients with paraprotein-related kidney disease continues to evolve.
浆细胞异常增生症是常见的恶性肿瘤，常通过单克隆免疫球蛋白（Ig）的产生与肾脏疾病相关。副蛋白可导致肾脏出现多种显著的病理形态，且目前在解释副蛋白介导的肾损伤的分子机制方面已取得进展。该领域的其他最新进展包括引入游离轻链检测和使用新型抗浆细胞药物，在某些情况下可逆转肾衰竭。在浆细胞病相关肾脏疾病患者的管理中，干细胞移植、血浆置换和肾移植的作用仍在不断发展。
