Watson B C, Freeman F J, Pool K D, Finitzo T, Chapman S B, Mendelsohn D, Devous M D, Schaefer S D, Close L G, Kondraske G V
Dallas Center for Vocal Motor Control, University of Texas.
J Speech Hear Res. 1991 Apr;34(2):269-78. doi: 10.1044/jshr.3402.269.
This study combines measures of linguistic and vocal performance and long-latency auditory electrophysiology to investigate task-dependent variability in spasmodic dysphonia (SD). Linguistic performance was evaluated using several measures of relatively complex linguistic ability (i.e., discourse analysis). Vocal performance was evaluated by measuring acoustic laryngeal reaction time (LRT) for tasks that differ in complexity. Normal structure of the cortex and subcortex was confirmed by magnetic resonance imaging. Cortical function was measured using multichannel quantitative auditory evoked potentials (AEPs). As a group, SD subjects who demonstrated subtle linguistic deficits also demonstrated prolonged LRT for the complex task and repeated and persistent auditory electrophysiologic abnormalities over the anterior quadrant of the left hemisphere. As a group, linguistically normal SD subjects demonstrated no significant increase in LRT for the complex task and no recurrent electrophysiologic abnormalities over the left anterior cortex relative to normal controls. Results support a neurogenic origin of SD and suggest that some aspects of inter- and intrasubject variability may be related to differences in loci and magnitude of cortical abnormalities.
本研究结合语言和发声表现的测量方法以及长潜伏期听觉电生理学，以研究痉挛性发声障碍（SD）中任务依赖的变异性。使用几种相对复杂的语言能力测量方法（即话语分析）来评估语言表现。通过测量不同复杂程度任务的声学喉反应时间（LRT）来评估发声表现。通过磁共振成像确认皮质和皮质下的正常结构。使用多通道定量听觉诱发电位（AEP）测量皮质功能。作为一个群体，表现出轻微语言缺陷的SD受试者在复杂任务中也表现出LRT延长，并且在左半球前象限出现反复和持续的听觉电生理异常。作为一个群体，语言正常的SD受试者在复杂任务中LRT没有显著增加，并且相对于正常对照组，左前皮质没有反复出现的电生理异常。结果支持SD的神经源性起源，并表明受试者间和受试者内变异性的某些方面可能与皮质异常的部位和程度差异有关。
