Moreno Lucas, Pollack Ian F, Duffner Patricia K, Geyer J Russell, Grill Jacques, Massimino Maura, Finlay Jonathan L, Zacharoulis Stergios
Department of Paediatrics, The Royal Marsden NHS Foundation Trust, Sutton, UK.
J Pediatr Hematol Oncol. 2010 Aug;32(6):515-8. doi: 10.1097/MPH.0b013e3181d7adf5.
The role of cytology of cerebrospinal fluid (CSF) has not been established in pediatric ependymoma. Thirty-two children with metastatic ependymoma were analyzed: 11 patients had only positive CSF cytology, 6 had only positive magnetic resonance imaging (MRI) findings, and 15 had both CSF cytology and MRI positive. Twenty-two patients relapsed. Five-year event-free survival was 27.3%+/-13.4% for children with only CSF positive (M1) versus 26.1%+/-10.2% for patients with positive spine MRI positive (with or without CSF positive, M3) (P=0.87). In conclusion, 34% of the patients with metastatic ependymoma were identified based on CSF cytology only and their outcome was comparable to patients with macroscopic disease. CSF cytology is a useful tool to stage newly diagnosed patients with ependymoma.
脑脊液（CSF）细胞学检查在小儿室管膜瘤中的作用尚未明确。对32例转移性室管膜瘤患儿进行了分析：11例患者脑脊液细胞学检查呈阳性，6例仅磁共振成像（MRI）检查结果呈阳性，15例脑脊液细胞学检查和MRI检查均呈阳性。22例患者复发。仅脑脊液呈阳性（M1）的患儿5年无事件生存率为27.3%±13.4%，脊柱MRI呈阳性（无论脑脊液是否呈阳性，M3）的患者5年无事件生存率为26.1%±10.2%（P = 0.87）。总之，34%的转移性室管膜瘤患者仅通过脑脊液细胞学检查得以确诊，其预后与有肉眼可见病变的患者相当。脑脊液细胞学检查是对新诊断的室管膜瘤患者进行分期的有用工具。
