Eliacik Mustafa, Karaman Erdur Sevil, Baltepe Altıok Inci, Gulkilik Gokhan, Aslan Cemile Anil, Kaya Faruk
Department of Ophthalmology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Department of Ophthalmology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Kaohsiung J Med Sci. 2016 Jan;32(1):38-43. doi: 10.1016/j.kjms.2015.12.004. Epub 2016 Jan 23.
In our study we aimed to evaluate the short-term effects of dorzolamide/timolol on ocular perfusion pressure and retrobulbar blood flow in patients with pseudoexfoliative glaucoma (PXG). This prospective observational cross-sectional study enrolled 22 eyes of 22 newly-diagnosed patients with PXG in a single center. All of the patients received a fixed combination of dorzolamide/timolol. Besides routine ophthalmologic examination, the retrobulbar hemodynamic parameters in the ophthalmic artery, central retinal artery, and short posterior ciliary arteries were measured in all participants at baseline and the 3(rd) month using color Doppler imaging. The mean intraocular pressure (IOP) was 22.3 ± 2.1 mmHg at baseline and reduced to 17.4 ± 2.3 mmHg at the 3(rd) month (p < 0.05). None of the retrobulbar parameters, except peak systolic velocity and resistive index in temporal short posterior ciliary arteries, changed significantly on therapy with dorzolamide/timolol fixed combination when the results were analyzed at Month 3. The drug significantly decreased the peak systolic velocity (p = 0.044) and reduced the resistive index in 0.04 units, 95% confidence interval 0.03-0.05, (p < 0.001) in the temporal short posterior ciliary arteries. This study reports that the retrobulbar hemodynamics might be affected less than expected by dorzolamide/timolol fixed combination in patients with PXG although the reduction of IOP was statistically significant.
在我们的研究中，我们旨在评估多佐胺/噻吗洛尔对假性剥脱性青光眼（PXG）患者眼灌注压和球后血流的短期影响。这项前瞻性观察性横断面研究在一个中心纳入了22例新诊断的PXG患者的22只眼。所有患者均接受多佐胺/噻吗洛尔固定复方制剂治疗。除常规眼科检查外，所有参与者在基线和第3个月时使用彩色多普勒成像测量眼动脉、视网膜中央动脉和睫状后短动脉的球后血流动力学参数。基线时平均眼压（IOP）为22.3±2.1 mmHg，第3个月时降至17.4±2.3 mmHg（p<0.05）。在第3个月分析结果时，除颞侧睫状后短动脉的收缩期峰值流速和阻力指数外，多佐胺/噻吗洛尔固定复方制剂治疗后其他球后参数均无显著变化。该药物显著降低了颞侧睫状后短动脉的收缩期峰值流速（p = 0.044），并使阻力指数降低了0.04个单位，95%置信区间为0.03 - 0.05，（p<0.001）。本研究报告称，尽管眼压降低具有统计学意义，但多佐胺/噻吗洛尔固定复方制剂对PXG患者球后血流动力学的影响可能比预期的要小。
