Januleviciene Ingrida, Ehrlich Rita, Siesky Brent, Nedzelskiené Irena, Harris Alon
Eye Clinic, Kaunas University of Medicine, Kaunas - Lithuania.
Eur J Ophthalmol. 2009 Sep-Oct;19(5):790-7. doi: 10.1177/112067210901900517.
To compare the effects of latanoprost/timolol (LTFC) versus dorzolamide/timolol (DTFC) fixed combinations on intraocular pressure (IOP), visual function, and retrobulbar blood flow in patients with open-angle glaucoma (OAG).
This was a prospective, randomized, double masked, parallel study on 30 patients with OAG. All patients received 4 weeks of timolol treatment prior to randomization to LTFC or DTFC treatment. Measurements after randomization were taken at 1, 6, and 12 months, including arterial blood pressure; IOP; color Doppler imaging of the ophthalmic artery (OA), central retinal artery, and short posterior ciliary artery (SPCA); scanning laser polarimetry; Humphrey visual field examination; and adverse events.
IOP decreased by 5.0 mmHg in the DTFC cohort (p<0.000) and 5.44 mmHg in the LTFC cohort (p=0.0001) after 12 months of treatment. No statistically significant differences in visual field or nerve fiber layer thickness were observed between the treatment groups during 12 months of therapy. Mean increase over 1 year of treatment in ocular perfusion and diastolic perfusion pressures were 10.46% and 10.67% in the DTFC group and 7.47% and 5.61% in the LTFC group, respectively. OA resistive index (RI) and SPCA RI were significantly different at the 12 months visit between the two treatment groups (p=0.05 and p=0.000, respectively): DTFC treatment showed decrease in the RI.
One year of treatment with LTFC or DTFC resulted in similar IOP lowering effects as well as stable visual function and structure. The DTFC group showed lower vascular resistance in retrobulbar vessels compared to the LTFC group.
比较拉坦前列素/噻吗洛尔（LTFC）与多佐胺/噻吗洛尔（DTFC）固定组合对开角型青光眼（OAG）患者眼压（IOP）、视觉功能和球后血流的影响。
这是一项针对30例OAG患者的前瞻性、随机、双盲、平行研究。所有患者在随机分组接受LTFC或DTFC治疗之前，均接受了4周的噻吗洛尔治疗。随机分组后的测量在第1、6和12个月进行，包括动脉血压、IOP、眼动脉（OA）、视网膜中央动脉和睫状后短动脉（SPCA）的彩色多普勒成像、扫描激光偏振imetry、Humphrey视野检查以及不良事件。
治疗12个月后，DTFC组的IOP降低了5.0 mmHg（p<0.000），LTFC组降低了5.44 mmHg（p=0.0001）。在12个月的治疗期间，治疗组之间在视野或神经纤维层厚度方面未观察到统计学上的显著差异。DTFC组治疗1年期间眼灌注压和舒张期灌注压的平均增加分别为10.46%和10.67%，LTFC组分别为7.47%和5. June 1%。在第12个月随访时，两个治疗组的OA阻力指数（RI）和SPCA RI存在显著差异（分别为p=0.05和p=0.000）：DTFC治疗显示RI降低。
LTFC或DTFC治疗1年导致相似的眼压降低效果以及稳定的视觉功能和结构。与LTFC组相比，DTFC组球后血管的血管阻力较低。
