Almeida Sara Regina Meira, Silva Luciano Bruno C, Guerreiro Carlos Alberto M, Nucci Anamarli
Department of Neurology, School of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
Arq Neuropsiquiatr. 2010 Apr;68(2):258-62. doi: 10.1590/s0004-282x2010000200020.
To verify how efficient respiratory parameters are in the follow-up of subjects with amyotrophic lateral sclerosis (ALS) and to observe possible correlations between respiratory and nutritional functions.
Sixteen patients with probable or defined ALS were selected and evaluated over eight months using the following respiratory parameters: spirometry, maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP), arterial gasometry and pulse oximetry; and nutritional parameters such as body mass index (BMI) and percentage weight loss.
P(a)CO(2) was a significant parameter to follow up disease evolution (p=0.051). There was significant correlation between MIP and MEP (r: 0.83); BMI and MIP (r: 0.70); BMI and MEP (r: 0.72); pulse oximetry and forced vital capacity (r: 0.57).
P(a)CO(2) was shown to be an efficient and significant parameter in the measurement of respiratory impairment; the correlations among MIP, MEP and BMI indicated that these are significant parameters for periodic clinical evaluation.
验证呼吸参数在肌萎缩侧索硬化症（ALS）患者随访中的有效性，并观察呼吸功能与营养功能之间可能存在的相关性。
选取16例可能或确诊为ALS的患者，在八个月的时间里使用以下呼吸参数进行评估：肺活量测定、最大吸气压力（MIP）、最大呼气压力（MEP）、动脉血气分析和脉搏血氧饱和度测定；以及营养参数，如体重指数（BMI）和体重减轻百分比。
动脉血二氧化碳分压（P(a)CO₂）是随访疾病进展的一个重要参数（p = 0.051）。MIP与MEP之间存在显著相关性（r：0.83）；BMI与MIP之间存在显著相关性（r：0.70）；BMI与MEP之间存在显著相关性（r：0.72）；脉搏血氧饱和度与用力肺活量之间存在显著相关性（r：0.57）。
P(a)CO₂被证明是测量呼吸功能损害的一个有效且重要的参数；MIP、MEP与BMI之间的相关性表明，这些参数对于定期临床评估具有重要意义。
