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Effects evoked by pentamethylenetetrazol-induced seizures upon N-acetylaspartate and N-acetylaspartylglutamate levels in different regions of the rat neuraxis.

作者信息

Brancati A, D'Arcangelo P

机构信息

Department of Experimental Medicine and Biochemical Sciences, University Tor Vergata, Rome, Italy.

出版信息

Life Sci. 1991;48(23):2229-32. doi: 10.1016/0024-3205(91)90337-b.

DOI:10.1016/0024-3205(91)90337-b
PMID:2046455
Abstract

We have examined the effects evoked by pentamethylenetetrazol (PTZ)-induced seizures upon the concentration of N-acetylaspartate (NAA) and of N-acetylaspartylglutamate (NAAG) in the forebrain, brainstem and spinal cord of rats. We observed a significant decrease of both NAA and NAAG in each one of the studied regions. These findings are consistent with an inhibitory role proposed in CNS for NAA and NAAG.

摘要

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