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Neurol Sci. 2010 Jun;31 Suppl 1:S99-101. doi: 10.1007/s10072-010-0296-3.
Multiple epidemiologic studies have reported a strong comorbidity between migraine and various psychiatric disorders. Migraine, depression and anxiety could share neurobiological abnormalities in the same neuronal networks. Derangement in central monoaminergic systems is probably the major physiopathological event involved. Abnormalities of metabolism of glutamate and GABA, substances controlling the balance, respectively, between excitation and inhibition in the central nervous system, have also been suggested. A mitochondrial cellular energy failure in the brain of migraine sufferers and psychiatric patients has finally been hypothesized. An antidepressive action of triptans has been suggested. Several antidepressant drugs play a role in migraine prevention. Some antiepileptic drugs have shown to be effective in the treatment of migraine and psychiatric disorders. Nutritional supplements acting on mitochondrial metabolism could improve migraine and depression.
多项流行病学研究报告称，偏头痛与各种精神疾病之间存在很强的共病关系。偏头痛、抑郁和焦虑可能在相同的神经元网络中存在神经生物学异常。中枢单胺能系统的紊乱可能是主要涉及的生理病理事件。谷氨酸和 GABA 代谢异常，分别控制着中枢神经系统兴奋与抑制之间的平衡，也被认为与此有关。偏头痛患者和精神疾病患者的大脑线粒体细胞能量衰竭也被假设为一种机制。曲坦类药物具有抗抑郁作用。几种抗抑郁药物在偏头痛预防中发挥作用。一些抗癫痫药物已被证明对偏头痛和精神疾病的治疗有效。作用于线粒体代谢的营养补充剂可能改善偏头痛和抑郁。
