Center for Reproductive Health, Cincinnati, OH 45219, USA.
J Assist Reprod Genet. 2010 Jul;27(7):383-9. doi: 10.1007/s10815-010-9421-8. Epub 2010 May 14.
Antral follicle count (AFC) is used as a marker of ovarian response. We assessed its value in predicting pregnancy outcomes in ovum donation cycles by retrospective review.
Oocyte donors (n = 94) underwent ovarian hyperstimulation using rFSH and GnRH-antagonists. Recipients were synchronized using GnRH-agonist down-regulation followed by fixed dose of estrogen and progesterone following hCG. Outcomes measured included correlation of AFC to pregnancy outcomes and cycle characteristics in those with and without clinical and ongoing-delivered cycles.
AFC significantly correlated with clinical [Exp beta 1.12; 95% CI: 1.02-1.23, p < 0.05] and ongoing-delivered pregnancy [Exp beta 1.10; 95% CI: 1.01-1.20, p < 0.05]. Significantly greater AFC, total and M-2 oocytes, and cycles resulting in cryopreserved embryos were seen in clinical and ongoing-delivered cycles.
AFC predicts cycle stimulation responses and clinical outcomes and may serve as a guide for dosing protocols and in choosing to proceed with the most optimal cycle.
窦卵泡计数（AFC）可作为卵巢反应的标志物。我们通过回顾性研究评估其在评估卵母细胞捐赠周期妊娠结局中的价值。
使用 rFSH 和 GnRH 拮抗剂对供卵者（n=94）进行卵巢超刺激。受者在 GnRH 激动剂下调后，使用固定剂量的雌激素和孕激素进行同步化，随后进行 hCG 治疗。测量的结果包括 AFC 与妊娠结局和有临床妊娠和持续妊娠周期与无临床妊娠和持续妊娠周期的周期特征的相关性。
AFC 与临床妊娠[Exp beta 1.12; 95% CI: 1.02-1.23, p < 0.05]和持续妊娠[Exp beta 1.10; 95% CI: 1.01-1.20, p < 0.05]显著相关。在临床妊娠和持续妊娠周期中，AFC、总卵母细胞和 M-2 卵母细胞以及导致冷冻胚胎的周期数量显著增加。
AFC 可预测周期刺激反应和临床结局，并可作为剂量方案选择和选择最佳周期的指导。
