肾病大鼠肾素和血管紧张素原的尿排泄
Urinary excretion of renin and angiotensinogen in nephrotic rats.
作者信息
Pedraza-Chaverrí J, Cruz C, Ibarra-Rubio M E, Hernández C, Tapia E, Peña J C
机构信息
Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de la Nutrición Salvador Zubirán, México, D.F., México.
出版信息
Nephron. 1991;57(1):106-8. doi: 10.1159/000186226.
Puromycin aminonucleoside (PA)-nephrotic rats have a high plasma renin activity (PRA) and low angiotensinogen levels. We measured proteinuria, urine renin, and urine angiotensinogen daily, for 11 days after PA injection. Proteinuria and urine angiotensinogen were evident on day 5, and urine renin on day 6. Peak levels of urine renin and angiotensinogen were attained on day 8. These data suggest that angiotensinogen urine excretion may contribute to its low plasma levels, and urine renin loss may limit a further increase in PRA.
嘌呤霉素氨基核苷（PA）肾病大鼠具有高血浆肾素活性（PRA）和低血管紧张素原水平。在注射PA后11天，我们每天测量蛋白尿、尿肾素和尿血管紧张素原。蛋白尿和尿血管紧张素原在第5天明显升高，尿肾素在第6天升高。尿肾素和血管紧张素原的峰值在第8天达到。这些数据表明，血管紧张素原的尿排泄可能导致其血浆水平降低，而尿肾素的丢失可能限制PRA的进一步升高。
Zotero 插件