Como P G, Kurlan R
Department of Neurology, University of Rochester School of Medicine, NY 14642.
Neurology. 1991 Jun;41(6):872-4. doi: 10.1212/wnl.41.6.872.
Obsessive-compulsive disorder (OCD) occurs commonly in association with Gilles de la Tourette's syndrome (GTS) and can be a major source of disability. Fluoxetine, a new antidepressant, has been effective for psychiatric patients with OCD. We conducted an open-label trial of fluoxetine (20 to 40 mg/d) for 32 GTS patients with OCD. After 1 week of treatment, six patients (16%) withdrew from the trial due to perceived lack of benefit. Data were analyzed for 26 patients (13 children and 13 adults) who were treated by a neurologist for 3 to 8 months. Following treatment, there was a significant reduction in scores on the Leyton Obsessional Inventory for both the adult and child groups, and 81% of patients reported a subjective improvement in obsessions and compulsions. Since fluoxetine was well tolerated, our findings indicate that the drug may be an effective agent for the treatment of OCD in GTS patients.
强迫症（OCD）常与图雷特综合征（GTS）并发，且可能成为致残的主要原因。新型抗抑郁药氟西汀对患有强迫症的精神科患者有效。我们对32例患有强迫症的GTS患者进行了一项氟西汀（20至40毫克/天）的开放标签试验。治疗1周后，6例患者（16%）因感觉无益处而退出试验。对26例患者（13名儿童和13名成人）的数据进行了分析，这些患者由神经科医生治疗3至8个月。治疗后，成人组和儿童组的莱顿强迫观念量表得分均显著降低，81%的患者报告强迫观念和强迫行为有主观改善。由于氟西汀耐受性良好，我们的研究结果表明该药物可能是治疗GTS患者强迫症的有效药物。
