Kurlan R, Como P G, Deeley C, McDermott M, McDermott M P
Department of Neurology, University of Rochester School of Medicine and Dentistry, New York.
Clin Neuropharmacol. 1993 Apr;16(2):167-72. doi: 10.1097/00002826-199304000-00009.
We carried out a double-blind, randomized, parallel-groups clinical trial of fluoxetine (20-40 mg/day) and placebo in 11 children with Tourette's syndrome (TS) and associated obsessive-compulsive symptoms (OCS). The treatment period lasted 4 months. No significant differences between treatment groups were observed for measures of OCS. Fluoxetine therapy, however, was associated with a trend toward some improvement in tic severity, attentional abilities, and social functioning. Given these observations and the limitations of this pilot study, which include selection biases, small sample size, and significant placebo effects, the efficacy of fluoxetine in children with TS deserves further larger-scale investigation.
我们对11名患有图雷特综合征（TS）及相关强迫症状（OCS）的儿童进行了一项关于氟西汀（20 - 40毫克/天）和安慰剂的双盲、随机、平行组临床试验。治疗期持续4个月。在OCS测量方面，各治疗组之间未观察到显著差异。然而，氟西汀治疗与抽动严重程度、注意力和社交功能的某种改善趋势相关。鉴于这些观察结果以及这项初步研究的局限性，包括选择偏倚、样本量小和显著的安慰剂效应，氟西汀在TS儿童中的疗效值得进一步进行更大规模的研究。
