Gulaia N M, Berdyshev A G, Chumak A A, Meged' E F, Kindruk N L, Gorid'ko T N
Biomed Khim. 2009 Nov-Dec;55(6):743-9.
It was shown for the first time that endogenous cannabimimetic compound N-stearoylethanolamine (NSE) administered at the dose 65 mg/kg of body weight during two weeks before anaphylaxis had cardioprotective properties on the model of anaphylactic shock in the guinea pigs. NSE reliably normalized the content of histamine and nitric oxide, decreased the activity both inducible and constitutive NO-synthases, prevented accumulation of thiobarbituric acid reactive substances (TBARS) and normalized the activity of catalase, superoxide dismutase and glutathione peroxidase in cardiomyocytes of animals under anaphylaxis. About of 70% of the NSE-treated animals survived under the anaphylactic shock. The present work indicates that NSE may influence the allergic reaction of immediate type and can possibly be used for design of a new type of antiallergic preparations and cardioprotective preparations as well.
首次表明，在豚鼠过敏反应前两周，以65毫克/千克体重的剂量给予内源性大麻素样化合物N-硬脂酰乙醇胺（NSE），对过敏性休克模型具有心脏保护作用。NSE可靠地使组胺和一氧化氮含量正常化，降低诱导型和组成型一氧化氮合酶的活性，防止硫代巴比妥酸反应性物质（TBARS）积累，并使过敏反应动物心肌细胞中的过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶活性正常化。约70%接受NSE治疗的动物在过敏性休克中存活。目前的研究表明，NSE可能影响速发型过敏反应，也可能用于设计新型抗过敏制剂和心脏保护制剂。
