Grände Per-Olof, Welling Karen-Lise, Eskesen Vagn, Romner Bertil
Universitetssygehuset i Lund, Anaestesi- og Intensivafdelingen, Denmark.
Ugeskr Laeger. 2010 May 10;172(19):1437-40.
A Cochrane metaanalysis and a study performed on children have recently confirmed that therapeutic hypothermia does not improve outcome after severe traumatic brain injury (TBI). TBI is not comparable to a short episode of global ischemia, where therapeutic hypothermia has been shown to improve outcome. The difference may be explained by the fact that hypothermia-induced stress after a traumatic brain injury reduces cerebral perfusion in the penumbra zone, where local circulation is already reduced. Thus, to date there is no indication for therapeutic hypothermia in TBI patients.
一项Cochrane荟萃分析以及一项针对儿童的研究最近证实，治疗性低温并不能改善重度创伤性脑损伤（TBI）后的预后。TBI与短暂的全脑缺血不同，后者已证明治疗性低温可改善预后。这种差异可能是由于创伤性脑损伤后低温诱导的应激会降低半暗带区域的脑灌注，而该区域的局部循环已经减少。因此，迄今为止，尚无证据表明TBI患者可进行治疗性低温治疗。
