Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Curr Opin Neurobiol. 2010 Aug;20(4):416-23. doi: 10.1016/j.conb.2010.04.010. Epub 2010 May 12.
Neural stem cells (NSCs) in the adult brain continuously supply new neurons to the hippocampal dentate gyrus (DG) and the olfactory bulb (OB). Recent studies indicate that the progression from neural precursor cells (NPCs) to mature neurons is tightly controlled by coordinate cell-intrinsic programs and external signals within the neurogenic niche. In this review, we summarize both classes of regulatory factors involved in distinct stages of adult neurogenesis, including proliferation and lineage differentiation of NSCs, migration of neuroblasts and integration of newborn neurons. A full understanding of the wide variety of signaling pathways will ultimately provide precise targets for therapeutic applications.
成体脑中的神经干细胞(NSCs)持续向海马齿状回(DG)和嗅球(OB)供应新的神经元。最近的研究表明,从神经前体细胞(NPCs)到成熟神经元的进展是由神经发生龛内的协调细胞内在程序和外部信号严格控制的。在这篇综述中,我们总结了参与成体神经发生不同阶段的这两类调节因子,包括 NSCs 的增殖和谱系分化、神经前体细胞的迁移以及新生神经元的整合。对广泛的信号通路的充分理解最终将为治疗应用提供精确的靶点。