Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Nat Rev Neurosci. 2010 May;11(5):339-50. doi: 10.1038/nrn2822. Epub 2010 Mar 31.
The integration of adult-born neurons into the circuitry of the adult hippocampus suggests an important role for adult hippocampal neurogenesis in learning and memory, but its specific function in these processes has remained elusive. In this article, we summarize recent progress in this area, including advances based on behavioural studies and insights provided by computational modelling. Increasingly, evidence suggests that newborn neurons might be involved in hippocampal functions that are particularly dependent on the dentate gyrus, such as pattern separation. Furthermore, newborn neurons at different maturation stages may make distinct contributions to learning and memory. In particular, computational studies suggest that, before newborn neurons are fully mature, they might function as a pattern integrator by introducing a degree of similarity to the encoding of events that occur closely in time.
成体神经元整合到成年海马的回路中表明，成年海马神经发生在学习和记忆中具有重要作用，但它在这些过程中的具体功能仍然难以捉摸。在本文中，我们总结了这一领域的最新进展，包括基于行为研究的进展和计算模型提供的见解。越来越多的证据表明，新生神经元可能参与到特别依赖齿状回的海马功能中，例如模式分离。此外，处于不同成熟阶段的新生神经元可能对学习和记忆有不同的贡献。特别是，计算研究表明，在新生神经元完全成熟之前，它们可能通过对时间上紧密发生的事件的编码引入一定程度的相似性，起到模式整合器的作用。
