Department of Plant Biology, Microbial and Plant Genomics Institute, University of Minnesota, 1500 Gortner Avenue, St. Paul, MN 55108, USA.
Curr Opin Plant Biol. 2010 Aug;13(4):459-65. doi: 10.1016/j.pbi.2010.04.006. Epub 2010 May 12.
Plants employ two modes of their innate immune system to resist pathogen infection. The first mode of immunity is referred to as pattern-triggered immunity (PTI) that is triggered by molecular patterns common to many types of microbes. The second mode is triggered by recognition of pathogen effectors and is called as effector-triggered immunity (ETI). At least some cases of PTI and ETI extensively share downstream signaling machinery, that is, PTI and ETI appear to be mediated by an integrated signaling network. However, activated immune responses in ETI are more prolonged and robust than those in PTI. Furthermore, network analysis has revealed that synergistic relationships among the signaling sectors are evident in PTI, which may amplify the signal, whereas compensatory relationships among the sectors dominate in ETI, explaining the robustness of ETI against genetic and pathogenic perturbations. Thus, plants seem to use a common signaling network differently in PTI and ETI.
植物利用其固有免疫系统的两种模式来抵抗病原体感染。第一种免疫模式称为模式触发免疫（PTI），它是由许多类型微生物共有的分子模式触发的。第二种模式是由识别病原体效应子触发的，称为效应子触发免疫（ETI）。至少在某些情况下，PTI 和 ETI 广泛共享下游信号机制，即 PTI 和 ETI 似乎是由一个集成的信号网络介导的。然而，ETI 中激活的免疫反应比 PTI 中的更持久和更强。此外，网络分析表明，在 PTI 中，信号转导区之间存在协同关系，这可能会放大信号，而在 ETI 中，区之间存在补偿关系，这解释了 ETI 对遗传和病原体扰动的稳健性。因此，植物似乎在 PTI 和 ETI 中以不同的方式使用共同的信号网络。
