动物中 microRNA 生物发生的转录后调控。

Posttranscriptional regulation of microRNA biogenesis in animals.

机构信息

Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

出版信息

Mol Cell. 2010 May 14;38(3):323-32. doi: 10.1016/j.molcel.2010.03.013.

DOI:10.1016/j.molcel.2010.03.013

PMID:20471939

Abstract

MicroRNAs (miRNAs) control gene expression in animals, plants, and unicellular eukaryotes by promoting degradation or repressing translation of target mRNAs. miRNA expression is often tissue specific and developmentally regulated, and regulation occurs both transcriptionally and posttranscriptionally. This regulation is crucial, as alteration of miRNA expression has been linked to human diseases, including several cancers. Here, we discuss recent studies that shed light on how multiple steps in the miRNA biogenesis pathway are regulated to modulate miRNA function in animals.

摘要

微小 RNA（miRNA）通过促进靶 mRNA 的降解或抑制翻译来控制动物、植物和单细胞真核生物中的基因表达。miRNA 的表达通常具有组织特异性和发育调控性，并且在转录和转录后水平都受到调节。这种调节至关重要，因为 miRNA 表达的改变与人类疾病有关，包括几种癌症。在这里，我们讨论了最近的研究，这些研究阐明了 miRNA 生物发生途径中的多个步骤如何受到调节，以调节动物中 miRNA 的功能。