Bahramiazar Peyvand, Abdollahzade Naseh, Tartibian Bakhtyar, Ahmadiasl Naser, Yaghoob Nezhad Fakhreddin
Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran.
Neurophysiology Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.
Adv Pharm Bull. 2024 Dec 30;14(4):819-835. doi: 10.34172/apb.39216. Epub 2024 Sep 15.
This review aims to elucidate the role of estrogen-sensitive microRNAs (miRNAs) in modulating brain functions and disorders, highlighting the protective effects of estrogen on the central nervous system.
A comprehensive literature review was conducted, examining the relationship between estrogen, miRNAs, and cognitive health. The study focused on experimental data comparing cognitive impairments between genders and the mechanisms of estrogen's effects on brain function.
Cognitive impairments are less prevalent in women of reproductive age compared to men, indicating estrogen's neuroprotective role. Estrogen modulates gene expression through specific receptors, while miRNAs regulate approximately 30% of protein-coding genes in mammals. These miRNAs play critical roles in synaptic plasticity and neuronal survival. The review identifies several estrogen-sensitive miRNAs and their potential involvement in brain disorders.
The interplay between estrogen and miRNAs offers valuable insights into the molecular mechanisms underlying cognitive health and disease. Understanding these relationships may lead to novel therapeutic strategies for addressing various brain disorders, particularly those associated with hormonal changes and aging.
本综述旨在阐明雌激素敏感型微小RNA（miRNA）在调节脑功能和脑疾病中的作用，强调雌激素对中枢神经系统的保护作用。
进行了全面的文献综述，研究雌激素、miRNA与认知健康之间的关系。该研究聚焦于比较性别间认知障碍的实验数据以及雌激素对脑功能影响的机制。
与男性相比，育龄期女性的认知障碍患病率较低，表明雌激素具有神经保护作用。雌激素通过特定受体调节基因表达，而miRNA在哺乳动物中调节约30%的蛋白质编码基因。这些miRNA在突触可塑性和神经元存活中起关键作用。该综述确定了几种雌激素敏感型miRNA及其在脑部疾病中的潜在作用。
雌激素与miRNA之间的相互作用为认知健康和疾病的分子机制提供了有价值的见解。了解这些关系可能会带来针对各种脑部疾病的新治疗策略，特别是那些与激素变化和衰老相关的疾病。
