Cordeiro Marco Antonio, de Carvalho Ana Elisa T S, Spadari Regina Celia
Laboratory of Stress Biology, Department of Biosciences, Health and Society Institute, Campus Baixada Santista, Federal University of Sao Paulo (UNIFESP), Santos 11020-015, SP, Brazil.
Int J Mol Sci. 2025 Jun 10;26(12):5566. doi: 10.3390/ijms26125566.
Cardiovascular diseases (CVDs) are the most prevalent cause of global mortality, highlighting the importance of understanding their molecular bases. Recently, small non-coding RNAs (miRNAS) were shown to affect messenger RNA (mRNA) stability, either by inhibiting translation or by causing degradation through base pairing with mRNAs, being negative regulators of protein translation. Moreover, miRNAs modulate many signaling pathways and cellular processes, including cell-to-cell communication. In the cardiovascular system, miRNAs control functions in cardiomyocytes, endothelial cells, smooth muscle cells, and fibroblasts. Because miRNA expression was detected in the blood of patients with various cardiovascular diseases, they are considered attractive candidates for noninvasive biomarkers. This study reviews the literature on the role played by miRNAs in heart development and diseases. The findings suggest that miRNA regulation may offer new perspectives for therapeutic interventions in heart diseases.
心血管疾病（CVDs）是全球死亡率最高的原因，这凸显了了解其分子基础的重要性。最近，小非编码RNA（miRNAs）被证明可通过抑制翻译或与mRNA碱基配对导致降解来影响信使RNA（mRNA）的稳定性，是蛋白质翻译的负调节因子。此外，miRNAs调节许多信号通路和细胞过程，包括细胞间通讯。在心血管系统中，miRNAs控制心肌细胞、内皮细胞、平滑肌细胞和成纤维细胞的功能。由于在各种心血管疾病患者的血液中检测到了miRNA表达，因此它们被认为是无创生物标志物的有吸引力的候选者。本研究综述了关于miRNAs在心脏发育和疾病中所起作用的文献。研究结果表明，miRNA调节可能为心脏病的治疗干预提供新的视角。
