Department of Obstetrics and Gynaecology, Academic Medical Centre, Amsterdam, The Netherlands.
Eur J Obstet Gynecol Reprod Biol. 2010 Aug;151(2):163-7. doi: 10.1016/j.ejogrb.2010.04.014. Epub 2010 May 15.
The incidence of ectopic pregnancy (EP) was reported to rise during the 1970s and 1980s; thereafter it remained stable or even declined. We studied whether changes in the incidence of pelvic inflammatory disease (PID) have had an impact on the incidence of EP and we hypothesise about the incidence of EP in the near future.
EP and PID hospital admissions from 1980 to 2005 were derived from Dutch Medical Registries and incidence trends were calculated and analysed by joinpoint regression.
The peak incidence of EP in 1988 (11/1000 live births) was preceded by a peak incidence of admissions for PID in 1983 (0.6/1000 women of all ages). The EP rate declined towards 2005 (7.3/1000 live births) mainly due to a decrease in EP in urban regions and in older aged women (> or =35 years). Presently, women <25 years and born between 1985 and 1990 are again at an increased risk of EP (12/1000 live births) but this rise was not preceded by a peak incidence of admissions for PID.
On a population level, the peak incidence of EP in The Netherlands was preceded by a peak incidence of PID. A renewed rise in the incidence of EP is observed for young women. This may be related to the significant increase in positive tests for genital Chlamydia trachomatis during recent years.
据报道，宫外孕（EP）的发病率在 20 世纪 70 年代和 80 年代上升；此后，它保持稳定甚至下降。我们研究了盆腔炎（PID）发病率的变化是否对 EP 的发病率产生了影响，并对 EP 的发病率进行了推测。
1980 年至 2005 年的 EP 和 PID 住院人数来自荷兰医疗登记处，通过连接点回归计算和分析发病率趋势。
EP 的发病率高峰出现在 1988 年（每 1000 例活产中 11 例），之前是 1983 年 PID 住院人数的高峰（所有年龄段妇女中每 1000 人中有 0.6 例）。EP 率向 2005 年下降（每 1000 例活产中 7.3 例），主要是由于城市地区和年龄较大的妇女（≥35 岁）的 EP 减少。目前，<25 岁和 1985 年至 1990 年出生的妇女再次面临 EP 的风险增加（每 1000 例活产中 12 例），但这一上升之前没有 PID 住院人数的高峰。
在人群水平上，荷兰 EP 的发病率高峰之前是 PID 的发病率高峰。年轻妇女的 EP 发病率再次上升。这可能与近年来生殖道沙眼衣原体阳性检测的显著增加有关。
