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对危及生命状况的认知:巴西严重孕产妇发病率监测网络中的异位妊娠

Awareness about a life-threatening condition: ectopic pregnancy in a network for surveillance of severe maternal morbidity in Brazil.

作者信息

Rocha Filho Edilberto Alves, Santana Danielly Scaranello, Cecatti Jose Guilherme, Costa Maria Laura, Haddad Samira Maerrawe, Parpinelli Mary Angela, Sousa Maria Helena, Camargo Rodrigo Soares, Pacagnella Rodolfo Carvalho, Surita Fernanda Garanhani, Pinto e Silva Joao Luiz

机构信息

Department of Obstetrics and Gynecology, School of Medicine, State University of Campinas, R. Alexander Fleming 101, 13083-881 Campinas, SP, Brazil.

Department of Obstetrics and Gynecology, School of Medicine, State University of Campinas, R. Alexander Fleming 101, 13083-881 Campinas, SP, Brazil ; Campinas Center for Studies in Reproductive Health (CEMICAMP), R. Vital Brasil 200, 13083-888 Campinas, SP, Brazil.

出版信息

Biomed Res Int. 2014;2014:965724. doi: 10.1155/2014/965724. Epub 2014 Mar 19.

Abstract

OBJECTIVE

To assess occurrence of severe maternal complications associated with ectopic pregnancy (EP).

METHOD

A multicenter cross-sectional study was conducted, with prospective surveillance of potentially life-threatening conditions (PLTC), maternal near miss (MNM), and maternal death (MD). EP complications, patient sociodemographic/obstetric characteristics, and conditions of severity management were assessed, estimating prevalence ratios with respective 95% CI. Factors independently associated with greater severity were identified using multiple regression analysis.

RESULTS

Of the 9.555 severe maternal morbidity patients, 312 women (3.3%) had complications after EP: 286 (91.7%) PLTC, 25 (8.0%) MNM, and 1 (0.3%) MD. Severe maternal outcome ratio (SMOR) was 0.3/1000 LB among EP cases and 10.8/1000 LB among other causes. Complicated EP patients faced a higher risk of blood transfusion, laparotomy, and lower risk of ICU admission and prolonged hospitalization than women developing complications resulting from other causes. Substandard care was the most common in more severe maternal morbidity and EP cases (22.7% MNM and MD versus 15% PLTC), although not significant.

CONCLUSION

Increased maternal morbidity due to EP raised awareness about the condition and its impact on female reproductive life. No important risk factors for greater severity were identified. Care providers should develop specific guidelines and interventions to prevent severe maternal morbidity.

摘要

目的

评估与异位妊娠(EP)相关的严重孕产妇并发症的发生情况。

方法

开展了一项多中心横断面研究,对潜在危及生命的情况(PLTC)、孕产妇接近死亡(MNM)和孕产妇死亡(MD)进行前瞻性监测。评估了EP并发症、患者的社会人口统计学/产科特征以及严重程度管理情况,估计患病率比值及各自的95%置信区间。使用多元回归分析确定与更高严重程度独立相关的因素。

结果

在9555例严重孕产妇发病患者中,312名女性(3.3%)在EP后出现并发症:286例(91.7%)为PLTC,25例(8.0%)为MNM,1例(0.3%)为MD。EP病例的严重孕产妇结局比率(SMOR)为0.3/1000活产,其他原因导致的并发症为10.8/1000活产。与因其他原因发生并发症的女性相比,EP并发症患者输血、剖腹手术的风险更高,入住重症监护病房和延长住院时间的风险更低。在更严重的孕产妇发病和EP病例中,护理不达标最为常见(MNM和MD为22.7%,PLTC为15%),尽管差异不显著。

结论

EP导致的孕产妇发病率增加提高了对该疾病及其对女性生殖生活影响的认识。未发现与更高严重程度相关的重要危险因素。护理提供者应制定具体指南和干预措施,以预防严重孕产妇发病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40a0/3977561/3e278f8501ac/BMRI2014-965724.001.jpg

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