6 天/周低蛋白饮食方案对年轻老年 2 型糖尿病患者抑郁症状的影响。

Effects of a 6-days-a-week low protein diet regimen on depressive symptoms in young-old type 2 diabetic patients.

机构信息

Department of Gerontology, Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy.

Department of Internal Medicine, University of Catania, Catania, Italy.

出版信息

Nutrition. 2011 Jan;27(1):46-49. doi: 10.1016/j.nut.2009.10.017. Epub 2010 May 15.

DOI:10.1016/j.nut.2009.10.017

PMID:20472399

Abstract

OBJECTIVES

Late-life depression is one of the main health problems among elderly diabetic subjects. In addition, depression is a common psychopathological condition among renal failure patients and most of these patients follow a low protein diet regimen (LPD). However, the effects of LPD on depressive symptoms are unclear.

DESIGN

In the present study, the effects of LPD regimen on depressive symptoms in elderly type 2 diabetic subjects with renal failure were investigated.

PARTICIPANTS

Fifty-two young-old type 2 diabetic patients with renal failure were enrolled in the study. All participants after normal protein diet regimen providing 1.2g/kg per d were instructed to consume either a LPD providing 0.8 g/kg per d, 7 d a wk (LPD 7/7), or a LPD providing 0.8 g/kg per d 6 d a wk (LPD 6/7) randomly.

RESULTS

Mean 15-item Geriatric Depression Scale (GDS-15) (2.0±0.6) and Beck Depression Inventory (BDI) (4.1±1.0), during normal protein diet regimen, significantly increased to (6.7±1.6) and (12.2±1.4), respectively, after LPD 7/7 (P<0.05 versus normal protein diet). However, after LPD 6/7, mean GDS-15 and BDI significantly decreased to (4.4±1.5) and (6.7±1.6), respectively (P<0.05 versus LPD 7/7).

CONCLUSION

LPD 6/7 regimen significantly decreased depressive symptoms in young-old type 2 diabetic patients.

摘要

目的

老年期抑郁症是老年糖尿病患者的主要健康问题之一。此外，抑郁症是肾衰竭患者常见的精神病理学状况，大多数这些患者遵循低蛋白饮食方案（LPD）。然而，LPD 对抑郁症状的影响尚不清楚。

设计

本研究调查了 LPD 方案对老年 2 型糖尿病合并肾衰竭患者抑郁症状的影响。

参与者

52 名年轻的 2 型糖尿病肾衰竭患者纳入研究。所有参与者在接受正常蛋白质饮食方案（提供 1.2g/kg/d）后，随机分为两组，一组接受 7 天/周的 LPD（提供 0.8 g/kg/d），另一组接受 6 天/周的 LPD（提供 0.8 g/kg/d）。

结果

正常蛋白质饮食方案时，平均 15 项老年抑郁量表（GDS-15）（2.0±0.6）和贝克抑郁量表（BDI）（4.1±1.0）显著升高至（6.7±1.6）和（12.2±1.4），分别在 LPD 7/7 后（P<0.05 与正常蛋白质饮食）。然而，在 LPD 6/7 后，GDS-15 和 BDI 的平均评分分别显著下降至（4.4±1.5）和（6.7±1.6）（P<0.05 与 LPD 7/7）。