Sucu Murat, Davutoğlu Vedat, Ozer Orhan, Aksoy Mehmet
Department of Cardiology, Medicine Faculty of Gaziantep University, Gaziantep, Turkey.
Turk Kardiyol Dern Ars. 2010 Mar;38(2):107-11.
We aimed to evaluate epidemiological, clinical, and microbiological features of infective endocarditis (IE) in a tertiary university hospital.
The study included 72 patients (31 women, 41 men; mean age 45+/-16 years; range 18 to 80 years) who were diagnosed as having definite IE, according to the modified Duke criteria, between 2004 and 2007. Data were reviewed on age, sex, underlying heart disease, predisposing conditions for bacteremia, echocardiographic and microbiological findings, treatment, complications, and mortality.
Infective endocarditis developed on a native valve in 47 (65.3%), a mechanical prosthetic valve in 21 (29.2%), and a pacemaker in two cases. The location of IE could not be determined in two cases (2.8%). Rheumatic heart disease (36.1%) was the most common preexisting valvular abnormality. The mitral valve was the most commonly affected valve in both native valves (43.1%) and prosthetic valves (13.9%). The most frequent symptom was fever (n=60, 83.3%). Electrocardiography showed abnormal findings in 24 cases (33.3%). Transthoracic and/or transesophageal echocardiography showed a vegetation in 63 cases (87.5%), moderate or severe mitral regurgitation in 41 cases (56.9%), aortic regurgitation in 21 cases (29.2%), and tricuspid regurgitation in 29 cases (40.3%). Staphylococci (26.4%) and streptococci (22.2%) were the most common causative agents. Cultures were negative in 26 cases (36.1%). Twenty patients (27.8%) underwent surgical treatment. Congestive heart failure (n=23, 31.9%) and cerebrovascular accidents (n=10, 13.9%) were the major complications. In-hospital mortality occurred in 11 cases (15.3%).
Our data reflect epidemiological, clinical, and microbiological profile of IE in a tertiary hospital located in the Southeastern Anatolia.
我们旨在评估一所三级大学医院中感染性心内膜炎（IE）的流行病学、临床和微生物学特征。
该研究纳入了72例患者（31名女性，41名男性；平均年龄45±16岁；范围18至80岁），这些患者在2004年至2007年间根据改良的杜克标准被诊断为确诊IE。对年龄、性别、基础心脏病、菌血症的易感因素、超声心动图和微生物学检查结果、治疗、并发症及死亡率等数据进行了回顾。
47例（65.3%）感染性心内膜炎发生在自身瓣膜，21例（29.2%）发生在机械人工瓣膜，2例发生在起搏器。2例（2.8%）病例的IE发病部位无法确定。风湿性心脏病（36.1%）是最常见的原有瓣膜异常。在自身瓣膜（43.1%）和人工瓣膜（13.9%）中，二尖瓣是最常受累的瓣膜。最常见的症状是发热（n = 60，83.3%）。心电图检查有异常发现的有24例（33.3%）。经胸和/或经食管超声心动图检查发现63例（87.5%）有赘生物，41例（56.9%）有中度或重度二尖瓣反流，21例（29.2%）有主动脉反流，29例（40.3%）有三尖瓣反流。葡萄球菌（26.4%）和链球菌（22.2%）是最常见的病原体。26例（36.1%）培养结果为阴性。20例（27.8%）接受了手术治疗。充血性心力衰竭（n = 23，31.9%）和脑血管意外（n = 10，13.9%）是主要并发症。11例（15.3%）患者在住院期间死亡。
我们的数据反映了位于安纳托利亚东南部的一所三级医院中IE的流行病学、临床和微生物学特征。
