Heydari Behrooz, Karimzadeh Iman, Khalili Hossein, Shojaei Esfandiar, Ebrahimi Abdolrasool
Depatrment of Clinical Pharmacy, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Depatrment of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Iran J Pharm Res. 2017 Winter;16(1):390-398.
BACKGROUND/OBJECTIVE: The aim of the present preliminary study was to assess the demographic, clinical, paraclinical, microbiological, echocardiographic, and therapeutic profile as well as in-hospital outcome of patients with infective endocarditis at a referral center for various infectious diseases in Iran.
Required demographic, clinical, plausible complications and paraclinical data were collected from patients' medical charts. Echocardiographic findings were obtained by performing transthoracic and/or transesophageal echocardiography as clinically indicated. In addition, details of management modalities and in-hospital outcome of patients were recorded.
During a 3-year period, 55 patients with definite or possible diagnosis of Infective endocarditis were admitted to the ward. Twenty one (38.2%) patients were injection drug users. and were the most commonly isolated microorganisms. Management modalities of Infective endocarditis included antimicrobial therapy alone (48 cases) and the combination of antimicrobial therapy and surgery (7 cases).
The rate of negative blood culture in our cohort is high. and were the most commonly isolated microorganisms from positive blood cultures. Congestive heart failure was the most frequent infective endocarditis complication as well as indication for surgery. In-hospital mortality rate of patients was unexpectedly low.
背景/目的：本初步研究的目的是评估伊朗一家各种传染病转诊中心感染性心内膜炎患者的人口统计学、临床、辅助临床、微生物学、超声心动图和治疗情况以及住院结局。
从患者病历中收集所需的人口统计学、临床、可能的并发症和辅助临床数据。根据临床指征，通过经胸和/或经食管超声心动图获得超声心动图检查结果。此外，记录患者的治疗方式细节和住院结局。
在3年期间，55例确诊或可能诊断为感染性心内膜炎的患者入住病房。21例（38.2%）患者为注射吸毒者。[此处原文缺失两种最常分离出的微生物名称]是最常分离出的微生物。感染性心内膜炎的治疗方式包括单纯抗菌治疗（48例）和抗菌治疗与手术联合（7例）。
我们队列中血培养阴性率较高。[此处原文缺失两种最常分离出的微生物名称]是血培养阳性中最常分离出的微生物。充血性心力衰竭是感染性心内膜炎最常见的并发症以及手术指征。患者的住院死亡率出乎意料地低。
