Department of Zoology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.
Integr Biol (Camb). 2010 Apr;2(4):178-82. doi: 10.1039/b927402b. Epub 2010 Feb 25.
A bewildering series of dynamic processes participate in the proper development of the complex architecture of the nervous system. Recent years have seen a growing interest in the role of mechanical forces in neural development. This is an exciting field of multidisciplinary study that encompasses biology, physics and engineering and enjoys both conceptual and technical recent advances in all of these areas. Here I present an update of very recent work on several related questions, including the role of neurite and axonal tension in the development of single neuron morphology, the effects of mechanical cues from the substrate, the role of tension in axonal pruning and synaptogenesis, and more. Particular emphasis is placed on the very recent and exciting shift from descriptive mechanics to a possible role for tension forces in neuronal and network function.
一系列令人困惑的动态过程参与了神经系统复杂结构的正常发育。近年来，人们对机械力在神经发育中的作用越来越感兴趣。这是一个令人兴奋的多学科研究领域，涵盖了生物学、物理学和工程学，并在所有这些领域都取得了概念和技术上的最新进展。在这里，我介绍了最近在几个相关问题上的工作进展，包括神经突和轴突张力在单个神经元形态发育中的作用、基质产生的机械线索的影响、张力在轴突修剪和突触形成中的作用，等等。特别强调的是，最近非常令人兴奋的转变，即从描述性力学转向张力在神经元和网络功能中的可能作用。
