Department of Clinical and Experimental Medicine, Amedeo Avogadro University, Division of Neurology, University Hospital Maggiore della Carità, Novara, Italy.
Curr Neurol Neurosci Rep. 2010 Jul;10(4):327-32. doi: 10.1007/s11910-010-0117-3.
Suicide is an important cause of premature death, and people with epilepsy are thought to be at increased risk for suicide. Antiepileptic drugs (AEDs) continue to be the mainstay of epilepsy treatment, but the benefits of seizure control must be balanced with their psychotropic potential. In recent years, suicidality has been recognized as a complication of several groups of drugs and, most recently, AEDs were implicated in an alert by the US Food and Drug Administration. The risk of suicidal ideation and behavior as side effects of AED treatment is low, and in people with epilepsy, such a risk must be balanced against the risk of not treating the seizures.
自杀是导致过早死亡的一个重要原因，癫痫患者被认为自杀风险增加。抗癫痫药物（AEDs）仍然是癫痫治疗的主要手段，但必须平衡其抗精神病潜力与控制癫痫发作的益处。近年来，自杀已被认为是几组药物的并发症，最近，美国食品和药物管理局的警报提示 AED 也与此有关。作为 AED 治疗副作用的自杀意念和行为风险较低，而对于癫痫患者，这种风险必须与不治疗癫痫发作的风险相平衡。
