Miller J H, Gates G F, Landing B H, Kogut M D, Roe T F
J Nucl Med. 1978 Apr;19(4):354-8.
Fifteen patients with glycogen-storage disease type 1 (von Gierke's disease) were evaluated by serial scintigraphy, with a clearly recognizable pattern of an enlarged liver with diminished radionuclide accumulation, splenomegaly with considerably increased uptake and renomegaly. In seven of these patients with GSD-1 scintigraphy demonstrated focal defects of varying size. Small or stable defects suggest benign hepatic adenomata, whereas malignant change occurred in growing large lesions. The potential malignant end-point of hepatic-cell carcinoma in GSD-1 warrants careful serial liver scintigraphy with scintiangiography on a routine basis.
对15例1型糖原贮积病（冯·吉尔克病）患者进行了系列闪烁扫描评估，发现了一种清晰可辨的模式，即肝脏肿大且放射性核素蓄积减少，脾脏肿大且摄取显著增加，还有肾脏肿大。在这些1型糖原贮积病患者中，7例闪烁扫描显示出大小各异的局灶性缺损。小的或稳定的缺损提示为良性肝腺瘤，而生长中的大病灶则发生了恶变。1型糖原贮积病中肝细胞癌的潜在恶性转归需要定期进行仔细的系列肝脏闪烁扫描及闪烁血管造影检查。
