Division of Medicine, Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Expert Rev Clin Immunol. 2009 Sep;5(5):593-604. doi: 10.1586/eci.09.30.
Celiac sprue (CS) is a gluten-sensitive enteropathy with many autoimmune features. CS involves multiple organs through immune and nonimmune processes, and is frequently associated with other autoimmune disorders. This article reviews the co-occurrence of CS with autoimmune disorders of the cutaneous, nervous, endocrine, musculoskeletal, gastrointestinal and cardiovascular systems. The types of autoimmune disorders associated with CS and the prevalence of CS in other autoimmune disorders are also discussed. A brief review of the literature on the potential mechanisms behind these associations and the therapeutic effects of a gluten-free diet for autoimmune comorbidities in CS is also provided.
乳糜泻（CS）是一种对麸质敏感的肠病，具有许多自身免疫特征。CS 通过免疫和非免疫过程涉及多个器官，并且常与其他自身免疫性疾病相关。本文综述了 CS 与皮肤、神经、内分泌、肌肉骨骼、胃肠道和心血管系统自身免疫性疾病的共同发生。还讨论了与 CS 相关的自身免疫性疾病的类型以及其他自身免疫性疾病中 CS 的患病率。本文还简要回顾了这些关联背后的潜在机制的文献以及无麸质饮食对 CS 自身免疫合并症的治疗效果。
