Goshgarian McKennah A, Laczek Jeffrey, Lustberg Michael
Gastroenterology, Uniformed Services University of the Health Sciences, Bethesda, USA.
Gastroenterology, Walter Reed National Military Medical Center, Bethesda, USA.
Cureus. 2024 Oct 28;16(10):e72571. doi: 10.7759/cureus.72571. eCollection 2024 Oct.
Collagenous sprue (CS) is a rare autoimmune gastrointestinal disorder characterized by specific histologic changes in the small intestine. It often presents with more severe symptoms and a worse prognosis compared to celiac disease, including significant malabsorption, weight loss, and nutrient deficiencies. Despite treatment with a gluten-free diet, symptom improvement is limited, with only a small fraction of patients responding positively. This case report highlights the diagnostic challenges and clinical features of CS in a 74-year-old woman, whose symptoms resolved following cessation of olmesartan. The case emphasizes the importance of recognizing medication-induced forms of the disease and outlines the need for targeted management strategies to improve patient outcomes.
胶原性口炎性腹泻（CS）是一种罕见的自身免疫性胃肠疾病，其特征是小肠出现特定的组织学变化。与乳糜泻相比，它通常表现出更严重的症状和更差的预后，包括严重的吸收不良、体重减轻和营养缺乏。尽管采用无麸质饮食进行治疗，但症状改善有限，只有一小部分患者有积极反应。本病例报告强调了一名74岁女性CS的诊断挑战和临床特征，其症状在停用奥美沙坦后得到缓解。该病例强调了认识药物诱导型疾病的重要性，并概述了制定针对性管理策略以改善患者预后的必要性。
