Department of Psychiatry, Social Psychiatry and Psychotherapy, Center for Addiction Research, Hannover Medical School, D-30625 Hanover, Germany.
Addict Biol. 2010 Jul;15(3):362-4. doi: 10.1111/j.1369-1600.2010.00215.x. Epub 2010 May 11.
Vascular endothelial growth factor A (VEGF-A) is a key regulator of angiogenesis. This study investigated VEGF-A serum levels during alcohol withdrawal (days 1, 7 and 14, 76 male patients, 38 healthy controls). Patients showed significantly higher VEGF-A serum levels (t = 2.620, P = 0.010), which increased significantly during withdrawal (F = 4.484, P = 0.014, mean difference = -36.835, P = 0.037). The increase of VEGF-A serum levels was significantly associated with initial breath alcohol concentration and the sumscore of the severity scale of alcohol dependence (SESA questionnaire, F = 5.252, P = 0.008). Increase of VEGF-A serum levels is closely associated to alcohol intoxication and severity of alcohol dependence.
血管内皮生长因子 A（VEGF-A）是血管生成的关键调节剂。本研究调查了酒精戒断期间（第 1、7 和 14 天，76 名男性患者，38 名健康对照）的 VEGF-A 血清水平。患者的 VEGF-A 血清水平明显升高（t = 2.620，P = 0.010），在戒断期间明显升高（F = 4.484，P = 0.014，平均差异 = -36.835，P = 0.037）。VEGF-A 血清水平的升高与初始呼气酒精浓度和酒精依赖严重程度量表（SESA 问卷）的总和显著相关（F = 5.252，P = 0.008）。VEGF-A 血清水平的升高与酒精中毒和酒精依赖的严重程度密切相关。
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