Soyka M, Gilg T, von Meyer L, Ora I
Psychiatrische Klinik, Universität München.
Wien Klin Wochenschr. 1991;103(22):684-9.
Serum methanol concentrations (SMC) exceeding 10 mg/l are highly suggestive of long-term alcohol intoxication and can be considered as marker for chronic alcohol abuse. Endogenously formed or consumed methanol is almost exclusively metabolized by alcohol dehydrogenase. As long as blood alcohol concentrations exceed 0.2-0.5 g/l methanol cannot be metabolized and accumulates. In a prospective study on 78 patients admitted for alcohol detoxification, elevated SMC up to 78 mg/l were found, with a mean SMC of 29.4 mg/l. No correlation was demonstrated between SMC and severity of the alcohol withdrawal syndrome. Further clinical, forensic and biochemical aspects of methanol metabolism are discussed.
血清甲醇浓度（SMC）超过10毫克/升高度提示长期酒精中毒，可被视为慢性酒精滥用的标志物。内源性生成或消耗的甲醇几乎完全由乙醇脱氢酶代谢。只要血液酒精浓度超过0.2 - 0.5克/升，甲醇就无法代谢并会蓄积。在一项对78名因酒精解毒入院患者的前瞻性研究中，发现SMC升高至78毫克/升，平均SMC为29.4毫克/升。未证明SMC与酒精戒断综合征的严重程度之间存在相关性。文中还讨论了甲醇代谢的进一步临床、法医和生化方面的问题。
