Department of Medicine, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.
J Gerontol A Biol Sci Med Sci. 2010 Aug;65(8):873-9. doi: 10.1093/gerona/glq068. Epub 2010 May 17.
The move from lying to standing is typically associated with a variety of physiological and neurohumoral changes, most especially a slight increase in systolic blood pressure (SBP). Decreased efficacy of the various mechanisms that control orthostatic blood pressure (BP) regulation may result in lightheadedness, dizziness, syncope, and cerebral hypoperfusion. The lack of effective orthostatic BP regulation is a symptom for various problems, including fatigue, depression, anxiety, and reduced attention.
This study examined men and women (N = 74) who were aged 30-75 years and asymptomatic for clinical orthostatic hypotension.
Relatively poor BP regulation in response to orthostasis was associated with decreased verbal memory, decreased concentration, and higher hopelessness scores.
Individuals who exhibited less effective SBP regulation even to a subsyndromal degree in response to an orthostatic challenge may be at increased risk for cognitive and affective problems. The relationship between orthostatic BP regulation is best described as curvilinear.
从躺着到站立的转变通常与各种生理和神经激素变化有关，尤其是收缩压（SBP）略有升高。控制直立血压（BP）调节的各种机制的功效降低可能导致头晕、头晕、晕厥和脑灌注不足。缺乏有效的直立血压调节是各种问题的症状，包括疲劳、抑郁、焦虑和注意力下降。
本研究检查了年龄在 30-75 岁之间且无直立性低血压临床症状的男性和女性（N=74）。
对直立的血压调节相对较差与言语记忆下降、注意力下降和绝望感评分升高有关。
即使在亚综合征程度下对直立性挑战的 SBP 调节效果较差的个体，患认知和情感问题的风险可能会增加。直立性血压调节之间的关系最好描述为曲线关系。
