JMJ14，一个 JmjC 结构域蛋白，在拟南芥中 RNA 沉默信号的 RNA 沉默和细胞间运动中是必需的。
JMJ14, a JmjC domain protein, is required for RNA silencing and cell-to-cell movement of an RNA silencing signal in Arabidopsis.
机构信息
Plant Sciences Department, Cambridge University, Cambridge, United Kingdom.
出版信息
Genes Dev. 2010 May 15;24(10):986-91. doi: 10.1101/gad.579910.
Abstract
JMJ14 is a histone H3 Lys4 (H3K4) trimethyl demethylase that affects mobile RNA silencing in an Arabidopsis transgene system. It also influences CHH DNA methylation, abundance of endogenous transposon transcripts, and flowering time. JMJ14 acts at a point in RNA silencing pathways that is downstream from RNA-dependent RNA polymerase 2 (RDR2) and Argonaute 4 (AGO4). Our results illustrate a link between RNA silencing and demethylation of histone H3 trimethylysine. We propose that JMJ14 acts downstream from the Argonaute effector complex to demethylate histone H3K4 at the target of RNA silencing.
摘要
JMJ14 是一种组蛋白 H3 赖氨酸 4（H3K4）三甲基化去甲基酶，它影响拟南芥转基因系统中的移动 RNA 沉默。它还影响 CHH DNA 甲基化、内源性转座子转录本的丰度和开花时间。JMJ14 在 RNA 依赖性 RNA 聚合酶 2（RDR2）和 Argonaute 4（AGO4）下游的 RNA 沉默途径中发挥作用。我们的结果说明了 RNA 沉默和组蛋白 H3 三甲基赖氨酸去甲基化之间的联系。我们提出，JMJ14 在 Argonaute 效应复合物的下游作用，以在 RNA 沉默的靶标处去甲基化组蛋白 H3K4。
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