双功能松香衍生胺硫脲催化剂催化内酯与 N-Boc-醛亚胺的高非对映选择性和对映选择性 Mannich 反应。
Highly diastereo- and enantioselective Mannich reaction of lactones with N-Boc-aldimines catalyzed by bifunctional rosin-derived amine thiourea catalysts.
机构信息
State Key Laboratory of Applied Organic Chemistry, Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, China.
出版信息
Chem Commun (Camb). 2010 Jun 28;46(24):4294-6. doi: 10.1039/c000621a. Epub 2010 May 17.
DOI:10.1039/c000621a
PMID:20480061
Abstract
A highly efficient diastereo- and enantioselective Mannich reaction of lactones with a variety of N-Boc-aldimines by using bifunctional rosin-derived amine thiourea catalysts was investigated for the first time, in general, affording the adducts bearing quaternary stereogenic centers with high levels of enantio- and diastereoselectivity (up to 99% ee, and >20:1 dr).
摘要
首次研究了多功能松香衍生的胺硫脲催化剂在各种 N-Boc-aldimine 与内酯的高对映选择性和非对映选择性曼尼希反应中的应用，通常可以得到带有季立体中心的加合物，具有高对映选择性和非对映选择性（高达 99%ee，>20:1dr）。
Zotero 插件